Article
Genetic analysis of the IRS. Pleiotropic effects of genes influencing insulin levels on lipoprotein and obesity measures.
Arteriosclerosis, thrombosis, and vascular biology - 1 Feb 1996
Mitchell B D, Kammerer C M, Mahaney M C, Blangero J, Comuzzie A G, Atwood L D, Haffner S M, Stern M P, MacCluer J W
Abstract excerpt
Insulin resistance is part of a metabolic syndrome that also includes non-insulin-dependent diabetes mellitus, dyslipidemia, obesity, and hypertension. It has been hypothesized that insulin resistance represents the primary physiological defect underlying this syndrome. Since insulin resistance is at least partially genetically determined, we hypothesized that genes influencing insulin resistance would have...
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