Article
Linkage of chromosomal markers on 4q with a putative gene determining maximal insulin action in Pima Indians.
Diabetes - 1 Apr 1993
Prochazka M, Lillioja S, Tait J F, Knowler W C, Mott D M, Spraul M, Bennett P H, Bogardus C
Abstract excerpt
Insulin action in vivo varies widely in nondiabetic Pima Indians. Not all of this variance is attributable to individual differences in obesity, physical fitness, sex, or age, and after correcting for these co-variates, measures of insulin action aggregate in families. Insulin action at maximally stimulating insulin concentrations has a trimodal frequency distribution, particularly among obese individuals. This...
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