The induction of proliferative vascular smooth muscle cell phenotypes by benzo[a]pyrene does not involve mutational activation of ras genes.

doi:10.1016/s0027-5107(96)00213-8

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Article

The induction of proliferative vascular smooth muscle cell phenotypes by benzo[a]pyrene does not involve mutational activation of ras genes.

Mutation research - 3 Feb 1997

Zhang Y, Ramos K S

Abstract excerpt

Previous studies in this laboratory have suggested that benzo[a]pyrene (BaP) challenge in vivo and in vitro induces genomic changes that result in the acquisition of proliferative vascular smooth muscle cell (SMC) phenotypes. Because this phenotypic change correlates with alterations in ras gene expression, and ras genes are known mutational targets of BaP, the present studies were conducted to determine if BaP...

Topics

Animals
Aorta
Benzo(a)pyrene
Cell Division
Cells, Cultured
Genes, ras
Male
Muscle, Smooth, Vascular
Mutation
Phenotype
Rats
Rats, Sprague-Dawley

Source

Open in PubMed

Identifiers

PMID: 9042412
DOI: 10.1016/s0027-5107(96)00213-8

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