Article
Polycyclic aromatic hydrocarbons induce an inflammatory atherosclerotic plaque phenotype irrespective of their DNA binding properties.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Aug 2005
Curfs Daniëlle M J, Knaapen Ad M, Pachen Daniëlle M F A, Gijbels Marion J J, Lutgens Esther, Smook Marjan L F, Kockx Mark M, Daemen Mat J A P, van Schooten Frederik J
Abstract excerpt
Although it has been demonstrated that carcinogenic environmental polycyclic aromatic hydrocarbons (PAHs) cause progression of atherosclerosis, the underlying mechanism remains unclear. In the present study, we aimed to investigate whether DNA binding events are critically involved in the progression of PAH-mediated atherogenesis. Apolipoprotein E knockout mice were orally (24 wk, once/wk) exposed to 5 mg/kg...
Topics
- Animals
- Apolipoproteins E
- Atherosclerosis
- Benzo(a)pyrene
- Benzopyrenes
- Cells, Cultured
- DNA
- DNA Adducts
- Flow Cytometry
- Male
- Mice
- Mice, Knockout
- Phenotype