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Article

Chronic exposure to the carcinogenic compound benzo[a]pyrene induces larger and phenotypically different atherosclerotic plaques in ApoE-knockout mice.

The American journal of pathology - 1 Jan 2004

Curfs Daniëlle M J, Lutgens Esther, Gijbels Marion J J, Kockx Mark M, Daemen Mat J A P, van Schooten Frederik J

Abstract excerpt

Benzo[a]pyrene (B[a]P) is a polycyclic aromatic hydrocarbon with atherogenic and carcinogenic properties. The role of B[a]P in carcinogenesis is well established, and thought to exert via enzymatic activation into reactive metabolites that are capable of binding to the DNA leading to uncontrolled proliferation. However, the mechanism underlying the atherogenic properties of B[a]P is still unclear. Therefore, the...

Topics

Animals
Apolipoproteins E
Apoptosis
Arteriosclerosis
Benzo(a)pyrene
DNA Adducts
Immunohistochemistry
Male
Mice
Mice, Knockout
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Time Factors

Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 14695324
DOI: 10.1016/S0002-9440(10)63101-X
PMCID: PMC1602243

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