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Article

A comparative study on the metabolic activation of 3,4-benzo[a]pyrene to mutagens by aorta smooth muscle cells of rat and rabbit.

Mutation research - 1 May 1990

Zwijsen R M, van Kleef E M, Alink G M

Abstract excerpt

The mutagenic activation of benzo[a]pyrene (BaP) after exposure to aorta smooth muscle cells of different origin was examined. Three test systems with different genetic endpoints--sister-chromatid exchange (SCE), gene mutation at the hypoxanthine guanine phosphoribosyl transferase (HGPRT) locus a...

Topics

Animals
Aorta
Arteriosclerosis
Benzo(a)pyrene
Biotransformation
DNA
Genes
Hypoxanthine Phosphoribosyltransferase
Male
Muscle, Smooth, Vascular
Mutagenicity Tests
Mutagens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Rabbits

Rats

Rats, Inbred Strains

Sister Chromatid Exchange

Source

Identifiers

PMID: 2342494
DOI: 10.1016/0027-5107(90)90048-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2342494-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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