The induction of proliferative vascular smooth muscle cell phenotypes by benzo(a)pyrene is characterized by up-regulation of inositol phospholipid metabolism and c-Ha-ras gene expression.

Abstract excerpt

Polycyclic aromatic hydrocarbons, such as benzo(a)pyrene (BaP), have been implicated in the initiation and progression of vascular lesions of atherosclerotic morphology in laboratory animals. In the present study, experiments were conducted to define the impact of repeated cycles of BaP challenge in vivo on the phenotypic expression of rat vascular (aortic) smooth muscle cells (SMCs). After eight weekly...

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