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Article

Subconductance states of a mutant NMDA receptor channel kinetics, calcium, and voltage dependence.

The Journal of general physiology - 1 Feb 1997

Premkumar L S, Qin F, Auerbach A

Abstract excerpt

The kinetic properties of main and subconductance states of a mutant mouse N-methyl-D-aspartate (NMDA) receptor channel were examined. Recombinant receptors made of zeta-epsilon 2 (NR1-NR2B) subunits having asparagine-to-glutamine mutations in the M2 segment (zeta N598Q/epsilon 2N589Q) were expressed in Xenopus oocytes. Single channel currents recorded from outside-out patches were analyzed using hidden Markov...

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Identifiers

PMID: 9041447
DOI: 10.1085/jgp.109.2.181
PMCID: PMC2220056

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