Article
Subconductance states of a mutant NMDA receptor channel kinetics, calcium, and voltage dependence.
The Journal of general physiology - 1 Feb 1997
Premkumar L S, Qin F, Auerbach A
Abstract excerpt
The kinetic properties of main and subconductance states of a mutant mouse N-methyl-D-aspartate (NMDA) receptor channel were examined. Recombinant receptors made of zeta-epsilon 2 (NR1-NR2B) subunits having asparagine-to-glutamine mutations in the M2 segment (zeta N598Q/epsilon 2N589Q) were expre...
Topics
- Animals
- Calcium
- Electrophysiology
- Ion Channel Gating
- Ion Channels
- Kinetics
- Markov Chains
- Membrane Potentials
- Mice
- Mice, Neurologic Mutants
- Models, Biological
- Mutation
- Patch-Clamp Techniques
- Receptors, N-Methyl-D-Aspartate
- Signal Processing, Computer-Assisted