Article

Molecular dynamics simulation of the truncated NMDA receptor in the open state

2025-09-18

Abstract excerpt

The GluN1/GluN2A N-methyl-D-aspartate receptor (NMDAR) is a critical ligand-gated ion channel in the central nervous system, playing essential roles in synaptic plasticity, learning, and memory. Understanding its dynamics in the open/active state is paramount for deciphering its physiological functions and for developing targeted therapeutics. Despite many past efforts, the active/open state has not yet been fully...

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Literature Corpus work: d54c8daa-8588-5a03-ac82-dbdd6a7c2867
DOI: 10.1101/2025.09.15.676349

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