Article
Myogenic cell lines derived from transgenic mice carrying a thermolabile T antigen: a model system for the derivation of tissue-specific and mutation-specific cell lines.
Developmental biology - 1 Apr 1994
Morgan J E, Beauchamp J R, Pagel C N, Peckham M, Ataliotis P, Jat P S, Noble M D, Farmer K, Partridge T A
Abstract excerpt
Skeletal myoblasts cloned from limb muscles of H-2Kb-tsA58 transgenic mice remained proliferative through at least 80 generations under conditions permissive for expression and function of the tsA58 gene product. When switched to nonpermissive conditions or implanted into muscles of nude mdx mice...
Topics
- Animals
- Antigens, Polyomavirus Transforming
- Cell Differentiation
- Cell Line
- Cell Transplantation
- Clone Cells
- H-2 Antigens
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Inbred CBA
- Mice, Transgenic
- Muscles
- Mutation
- Organ Specificity