Article
Yeast RAS2 mutations modulating the ras-guanine exchange factor interaction.
FEBS letters - 10 Feb 1997
Hermann-Le Denmat S, Jacquet M
Abstract excerpt
We have used a two-hybrid approach to test various forms of Saccharomyces cerevisiae Ras2p for their ability to interact with the human guanine nucleotide exchange factor HGRF55. We have previously shown that a strong two-hybrid interaction is found between the HGRF55p and the dominant negative Ras2p(G22A) form of ras [Camus et al. (1995) Oncogene 11, 951-959]. We show here that the substitution N123I which...
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