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Article

The highly metastatic 4T1 breast carcinoma model possesses features of a hybrid epithelial/mesenchymal phenotype.

Disease models & mechanisms - 1 Sept 2024

Herndon Mary E, Ayers Mitchell, Gibson-Corley Katherine N, Wendt Michael K, Wallrath Lori L, Henry Michael D, Stipp Christopher S

Abstract excerpt

Epithelial-mesenchymal transitions (EMTs) are thought to promote metastasis via downregulation of E-cadherin (also known as Cdh1) and upregulation of mesenchymal markers such as N-cadherin (Cdh2) and vimentin (Vim). Contrary to this, E-cadherin is retained in many invasive carcinomas and promotes collective cell invasion. To investigate how E-cadherin regulates metastasis, we examined the highly metastatic,...

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Source

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Identifiers

PMID: 39104192
DOI: 10.1242/dmm.050771
PMCID: PMC11391819

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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