Article
Temperature-sensitive cdc7 mutations of Saccharomyces cerevisiae are suppressed by the DBF4 gene, which is required for the G1/S cell cycle transition.
Genetics - 1 May 1992
Kitada K, Johnston L H, Sugino T, Sugino A
Abstract excerpt
When present on a multicopy plasmid, a gene from a Saccharomyces cerevisiae genomic library suppresses the temperature-sensitive cdc7-1 mutation. The gene was identified as DBF4, which was previously isolated by complementation in dbf4-1 mutant cells and is required for the G1----S phase progression of the cell cycle. DBF4 has an open reading frame encoding 695 amino acid residues and the predicted molecular mass...
Topics
- Alleles
- Amino Acid Sequence
- Base Sequence
- G1 Phase
- Genes, Fungal
- Genes, Suppressor
- Mitosis
- Molecular Sequence Data
- Mutation
- Open Reading Frames
- Plasmids