Article
A bias in the alphabeta T cell receptor variable region gene usage in Takayasu's arteritis.
Clinical and experimental immunology - 1 Feb 1997
Nityanand S, Giscombe R, Srivastava S, Hjelmström P, Sanjeevi C B, Sinha N, Grunewald J, Lefvert A K
Abstract excerpt
Takayasu's arteritis (TA) is a chronic large vessel vasculitis with a predilection for the aortic arch and its branches. T lymphocytes may be important in the pathogenesis, as they have been found to infiltrate the vascular lesions. To elucidate further the role of T cells in the disease, we studied circulating CD4+ and CD8+ T cells, expression of the activation marker (HLA-DR), marker for naive (CD45RA) and...
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