Article
Influence of allelic variation on apolipoprotein(a) folding in the endoplasmic reticulum.
The Journal of biological chemistry - 21 Feb 1997
White A L, Guerra B, Lanford R E
Abstract excerpt
Plasma levels of lipoprotein(a) (Lp(a)) vary over 1000-fold between individuals and are determined by the gene for its unique apolipoprotein, apo(a), which has greater than 100 alleles. Using primary baboon hepatocyte cultures, we previously demonstrated that differences in the ability of apo(a) allelic variants to escape the endoplasmic reticulum (ER) are a major determinant of Lp(a) production rate. To examine...
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