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Article

Molecular basis for "null" lipoprotein(a) phenotypes and the influence of apolipoprotein(a) size on plasma lipoprotein(a) level in the baboon.

The Journal of biological chemistry - 25 Mar 1994

White A L, Hixson J E, Rainwater D L, Lanford R E

Abstract excerpt

High plasma levels of lipoprotein(a) (Lp(a)) and its unique apolipoprotein, apo(a), are an independent risk factor for cardiovascular disease. Plasma Lp(a) levels vary over a 1000-fold range and are determined by the apo(a) locus, which has at least 34 alleles expressing apo(a) isoforms with molecular weights from < 300,000 to > 800,000. In addition, "null" apo(a) alleles produce no detectable plasma apo(a). We...

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PMID: 8132643

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