Article
Intracellular processing of apo(a) in primary baboon hepatocytes.
Chemistry and physics of lipids - 1 Jan 1994
White A L, Rainwater D L, Hixson J E, Estlack L E, Lanford R E
Abstract excerpt
We have developed a serum-free medium for the long-term culture of highly differentiated primary baboon hepatocytes. Hepatocytes isolated from animals with defined plasma Lp(a) levels and apo(a) glycoprotein phenotypes were used to study the assembly of Lp(a). A combination of steady-state and pulse-chase labeling studies and endoglycosidase digests demonstrated that apo(a) was synthesized as a lower molecular...
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