Article
Over-expression of GATA-6 in Xenopus embryos blocks differentiation of heart precursors.
The EMBO journal - 15 Jan 1997
Gove C, Walmsley M, Nijjar S, Bertwistle D, Guille M, Partington G, Bomford A, Patient R
Abstract excerpt
Xenopus GATA-6 transcripts are first detected at the beginning of gastrulation in the mesoderm, and subsequent domains of expression include the field of cells shown to have heart-forming potential. In this region, GATA-6 expression continues only in those cells that go on to form the heart; however, a decrease occurs prior to terminal differentiation. Artificial elevation of GATA-6, but not GATA-1, prevents...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.