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Article

Multigenetic lesions in infant acute leukaemias: correlations with ALL-1 gene status.

British journal of haematology - 1 Feb 1997

Cimino G, Lanza C, Elia L, Lo Coco F, Gaidano G, Biondi A, Pastore C, Serra A, Canaani E, Croce C M, Mandelli F, Saglio G

Abstract excerpt

In this study we investigated the presence of structural lesions in the ALL-1, p53 and p16 (cyclin-dependent kinase 4 inhibitor) genes in leukaemic cells obtained from 22 patients with infant acute leukaemia (aged < 18 months). Of these, 18 cases were classified as acute lymphoblastic leukaemia (ALL) and four as acute myeloid leukaemia (AML). Tumour DNAs were analysed by a combination of Southern blot. polymerase...

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PMID: 9029018
DOI: 10.1046/j.1365-2141.1997.d01-2044.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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