Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fetal Hemoglobin in Sickle Cell Anemia: Determinants of Response to Hydroxyurea

1 Feb 1997

Abstract excerpt

Hydroxyurea (HU) can increase fetal hemoglobin (HbF) in sickle cell anemia (HbSS). To identify determinants of the HbF response, we studied 150 HU-treated patients grouped by quartiles of change in HbF from baseline to 2 years. Half of the HU-assigned patients had long-term increments in HbF. In the top two quartiles, HbF increased to 18.1% and 8.8%. These patients had the highest baseline neutrophil and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood groups and transfusion
Share to Hemoglobinopathies and Related Disorders
Share to Prenatal Screening and Diagnostics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 9028341
DOI: 10.1182/blood.v89.3.1078

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fetal Hemoglobin in Sickle Cell Anemia: Determinants of Response to HydroxyureaPMID 9028341Read ↗

Fetal hemoglobin in sickle cell anemia: genetic determinants of response to hydroxyurea.Semantic proximity Read ↗

Fetal Hemoglobin and F-Cell Responses to Long-Term Hydroxyurea Treatment in Young Sickle Cell PatientsSemantic proximity Read ↗

Emerging science of hydroxyurea therapy for pediatric sickle cell disease.Semantic proximity Read ↗

Epigenetic and molecular profiles of erythroid cells after hydroxyurea treatment in sickle cell anemiaSemantic proximity Read ↗

The role of BCL11A and HMIP-2 polymorphisms on endogenous and hydroxyurea induced levels of fetal hemoglobin in sickle cell anemia patients from southern Brazil.Semantic proximity Read ↗

A systematic review of known mechanisms of hydroxyurea-induced fetal hemoglobin for treatment of sickle cell disease.Semantic proximity Read ↗

HbF/F-cell and the Phenotype of Sickle Cell DiseaseSemantic proximity Read ↗

Mean Corpuscular Hemoglobin Modulates HbF /F‐Cell and Clinical Response to Gene Therapy and Hydroxyurea in Sickle Cell DiseaseSemantic proximity Read ↗

Fetal hemoglobin in sickle cell anemia: The Arab-Indian haplotype and new therapeutic agents.Semantic proximity Read ↗

Fetal hemoglobin in sickle cell anemia.Semantic proximity Read ↗

Whole exome sequencing identifies novel genes for fetal hemoglobin response to hydroxyurea in children with sickle cell anemia.Semantic proximity Read ↗

Mechanism for fetal hemoglobin induction by hydroxyurea in sickle cell erythroid progenitorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.