Article
Single amino acid changes alter the repair specificity of Drosophila Rrp1. Isolation of mutants deficient in repair of oxidative DNA damage.
The Journal of biological chemistry - 23 Dec 1994
Gu L, Huang S M, Sander M
Abstract excerpt
Drosophila Rrp1 has several tightly associated enzymatic activities, including double-strand DNA 3'-exonuclease, apurinic/apyrimidinic endonuclease, 3'-phosphatase, and 3'-phosphodiesterase. The carboxyl-terminal third of Rrp1, homologous to Escherichia coli exonuclease III, is sufficient to repa...
Topics
- Amino Acid Sequence
- Amino Acids
- Animals
- Base Sequence
- DNA Damage
- DNA Primers
- DNA Repair
- Drosophila
- Drosophila Proteins
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Nucleotidyltransferases
- Oxidation-Reduction
- Polymerase Chain Reaction
- Sequence Homology, Amino Acid
- Substrate Specificity