Article
Characterization of mutations in DNA gyrase and topoisomerase IV Involved in quinolone resistance of Mycoplasma gallisepticum mutants obtained in vitro.
Antimicrobial agents and chemotherapy - 1 Feb 2002
Reinhardt A K, Bébéar C M, Kobisch M, Kempf I, Gautier-Bouchardon A V
Abstract excerpt
Mycoplasma gallisepticum enrofloxacin-resistant mutants were generated by stepwise selection in increasing concentrations of enrofloxacin. Alterations were found in the quinolone resistance-determining regions of the four target genes encoding DNA gyrase and topoisomerase IV from these mutants. This is the first description of such mutations in an animal mycoplasma species.
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