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Article

Association of a polymorphic variant of the Werner helicase gene with myocardial infarction in a Japanese population.

American journal of medical genetics - 11 Feb 1997

Ye L, Miki T, Nakura J, Oshima J, Kamino K, Rakugi H, Ikegami H, Higaki J, Edland S D, Martin G M, Ogihara T

Abstract excerpt

The Werner syndrome (WS) is a rare autosomal recessive progeroid syndrome characterized by the premature onset of multiple age-related disorders, including atherosclerosis, cancer, non-insulin-dependent diabetes mellitus (NIDDM), ocular cataracts and osteoporosis [Epstein et al., 1966]. The major...

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Source

Identifiers

PMID: 9021029
DOI: 10.1002/(sici)1096-8628(19970211)68:4<494::aid-ajmg30>3.0.co;2-l

Genes

WRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-9021029-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of a polymorphic variant of the Werner helicase gene with myocardial infarction in a Japanese population.PMID 9021029Read ↗

Polymorphisms at the Werner locus: I. Newly identified polymorphisms, ethnic variability of 1367Cys/Arg, and its stability in a population of Finnish centenarians.Semantic proximity Read ↗

Polymorphisms at the Werner locus: II. 1074Leu/Phe, 1367Cys/Arg, longevity, and atherosclerosis.Semantic proximity Read ↗

Werner syndrome protein 1367 variants and disposition towards coronary artery disease in Caucasian patients.Semantic proximity Read ↗

Frequency of Werner helicase 1367 polymorphism and age-related morbidity in an elderly Brazilian population.Semantic proximity Read ↗

The clinical characteristics of Werner syndrome: molecular and biochemical diagnosis.Semantic proximity Read ↗

Genetic variation in WRN and ischemic stroke: General population studies and meta-analyses.Semantic proximity Read ↗

Molecular and epidemiological studies of Werner syndrome in the Japanese population.Semantic proximity Read ↗

WRN gene 1367 Arg allele protects against development of type 2 diabetes mellitus.Semantic proximity Read ↗

Genetic risk for myocardial infarction in Japanese individuals with or without chronic kidney disease.Semantic proximity Read ↗

Homozygosity for the WRN Helicase-Inactivating Variant, R834C, does not confer a Werner syndrome clinical phenotype.Semantic proximity Read ↗

Mutation and haplotype analyses of the Werner's syndrome gene based on its genomic structure: genetic epidemiology in the Japanese population.Semantic proximity Read ↗

Impact of genetic variations in the WRN gene on age related pathologies and mortality.Semantic proximity Read ↗

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