Article
DNA alterations in sporadic colorectal tumors do not correlate with tumor staging diagnosed by the TNM system.
Cancer letters - 3 Dec 1996
Deuter R, Linz J, Pietsch S, Winde G, Hentsch S, Müller O
Abstract excerpt
Blood normal and tumor tissue samples of 23 patients with sporadic colorectal tumors were screened for DNA alterations in the tumor relevant genes APC, K-ras, DCC and p53. Six different microsatellite regions were analyzed for instability by a new developed non-radioactive method. Somatic DNA alterations were found in 17 tumor samples: 13 carried single or multiple changes in single genes; six carried alterations...
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