Microsatellite instability in human colonic cancer is not a useful clinical indicator of familial colorectal cancer.

doi:10.1016/0016-5085(95)90742-4

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Microsatellite instability in human colonic cancer is not a useful clinical indicator of familial colorectal cancer.

Gastroenterology - 1 Dec 1995

Samowitz W S, Slattery M L, Kerber R A

Abstract excerpt

BACKGROUND & AIMS: Microsatellite instability is a property of most tumors occurring in the context of hereditary nonpolyposis colon cancer. Instability also occurs in 10%-15% of apparently sporadic colorectal cancers, and it has been hypothesized that this instability may indicate a genetic pred...

Topics

Adult
Aged
Base Sequence
Case-Control Studies
Chi-Square Distribution
Colonic Neoplasms
Colorectal Neoplasms
Family Health
Female
Genotype
Glutathione Transferase
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Microsatellite Repeats

Middle Aged

Molecular Sequence Data

Polymerase Chain Reaction

Predictive Value of Tests

Source

Open in PubMed

Identifiers

PMID: 7498640
DOI: 10.1016/0016-5085(95)90742-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7498640-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Microsatellite instability in human colonic cancer is not a useful clinical indicator of familial colorectal cancer.PMID 7498640Read ↗

Human Papillomavirus DNA Is Rarely Detected in Colorectal Carcinomas and Not Associated with Microsatellite Instability: The Seattle Colon Cancer Family RegistrySemantic proximity Read ↗

Comparison of clinicopathologic characteristics and genetic alterations between microsatellite instability-positive and microsatellite instability-negative sporadic colorectal carcinomas in patients younger than 40 years old.Semantic proximity Read ↗

Clinical implications of microsatellite instability in colorectal cancers.Semantic proximity Read ↗

Microsatellite Instability in Adenomas as a Marker for Hereditary Nonpolyposis Colorectal CancerSemantic proximity Read ↗

Microsatellite instability in colitis associated colorectal cancer.Semantic proximity Read ↗

Microsatellite instability in colorectal adenomas: relevance and clinical importance.Semantic proximity Read ↗

The value of microsatellite instability in the detection of HNPCC families and of sporadic colorectal cancers with special biological features: an investigation on a series of 100 consecutive cases.Semantic proximity Read ↗

Microsatellite instability in a population of sporadic colorectal cancers: correlation between genetic and pathological profiles.Semantic proximity Read ↗

Microsatellite instability is rare in rectal carcinomas and signifies hereditary cancerSemantic proximity Read ↗

The clinical utility of microsatellite instability in colorectal cancerSemantic proximity Read ↗

Microsatellite instability in sporadic colon cancer is associated with an improved prognosis at the population level.Semantic proximity Read ↗

The colon cancer burden of genetically defined hereditary nonpolyposis colon cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.