Article
Impaired lysogenisation of the Escherichia coli rpoA341 mutant by bacteriophage lambda is due to the inability of CII to act as a transcriptional activator.
Molecular & general genetics : MGG - 16 Apr 1997
Obuchowski M, Giladi H, Koby S, Szalewska-Pałasz A, Wegrzyn A, Oppenheim A B, Thomas M S, Wegrzyn G
Abstract excerpt
The C-terminus of the alpha subunit of Escherichia coli RNA polymerase is known to function in transcriptional activation at certain promoters. This region was previously shown to be necessary for full activation of the pE promoter by the phage lambda CII protein in vitro. In this work we investigated the inability of phage lambda to follow the lysogenic pathway in cells carrying the point mutation rpoA341 (a...
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