Article
BMP7 null mutation in mice: developmental defects in skeleton, kidney, and eye.
Experimental cell research - 10 Jan 1997
Jena N, Martín-Seisdedos C, McCue P, Croce C M
Abstract excerpt
While generating bcl2 alpha transgenic mice, we found some F2 offspring of one of the transgenic lines which were very small and had closed eyes at the time of weaning. These pups died within 1 month after birth. In order to determine the molecular basis of this phenotype, we screened a genomic l...
Topics
- Abnormalities, Multiple
- Animals
- Animals, Newborn
- Base Sequence
- Bone Morphogenetic Protein 7
- Bone Morphogenetic Proteins
- Bone and Bones
- DNA Primers
- Eye Abnormalities
- Female
- Genes, bcl-2
- Homozygote
- Kidney
- Male
- Mice
- Mice, Knockout
- Mutagenesis, Insertional
- Phenotype