Article
A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye.
Genes & development - 15 Nov 1995
Dudley A T, Lyons K M, Robertson E J
Abstract excerpt
BMP-7/OP-1, a member of the transforming growth factor-beta (TGF-beta) family of secreted growth factors, is expressed during mouse embryogenesis in a pattern suggesting potential roles in a variety of inductive tissue interactions. The present study demonstrates that mice lacking BMP-7 display severe defects confined to the developing kidney and eye. Surprisingly, the early inductive tissue interactions...
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