Article
PACT: cloning and characterization of a cellular p53 binding protein that interacts with Rb.
Oncogene - 16 Jan 1997
Simons A, Melamed-Bessudo C, Wolkowicz R, Sperling J, Sperling R, Eisenbach L, Rotter V
Abstract excerpt
Cellular functions of tumor suppressor proteins can be mediated by protein-protein interactions. Using p53 as a probe to screen an expression library, a cDNA encoding a 250 kDa protein was isolated. Recombinant forms of this protein, designated PACT, bind to wild type p53 while two different muta...
Topics
- Alternative Splicing
- Animals
- Base Sequence
- Carrier Proteins
- Cloning, Molecular
- DNA
- Humans
- Male
- Mice
- Molecular Sequence Data
- Mutation
- RNA-Binding Proteins
- Retinoblastoma Protein
- Ribonucleoproteins, Small Nuclear
- Testis
- Tumor Suppressor Protein p53