Article
Dissecting independent channel and scaffolding roles of the Drosophila transient receptor potential channel.
The Journal of cell biology - 21 Nov 2005
Wang Tao, Jiao Yuchen, Montell Craig
Abstract excerpt
Drosophila transient receptor potential (TRP) serves dual roles as a cation channel and as a molecular anchor for the PDZ protein, INAD (inactivation no afterpotential D). Null mutations in trp cause impairment of visual transduction, mislocalization of INAD, and retinal degeneration. However, the impact of specifically altering TRP channel function is not known because existing loss-of-function alleles greatly...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Animals, Genetically Modified
- Antiporters
- Arrestins
- Blotting, Western
- Calcium
- Cations
- Drosophila Proteins
- Drosophila melanogaster
- Electroretinography
- Gene Expression Regulation
- Genes, Insect