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Article

Trp64Arg mutation of beta3-adrenergic receptor in essential hypertension: insulin resistance and the adrenergic system.

American journal of hypertension - 1 Jan 1997

Fujisawa T, Ikegami H, Yamato E, Hamada Y, Kamide K, Rakugi H, Higaki J, Murakami H, Shimamoto K, Ogihara T

Abstract excerpt

A putative pathogenic mutation in the beta3-adrenergic receptor gene (Trp64Arg) has been reported to be associated with higher diastolic blood pressure as well as clinical features of the insulin resistance syndrome and an earlier onset of non-insulin-dependent diabetes mellitus (NIDDM) in Pima Indians and Finns. Because essential hypertension is reported to be associated with insulin resistance, we studied the...

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Identifiers

PMID: 9008254
DOI: 10.1016/s0895-7061(96)00297-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Trp64Arg mutation of beta3-adrenergic receptor in essential hypertension: insulin resistance and the adrenergic system.PMID 9008254Read ↗

Prevalence of the Trp64Arg missense mutation of the beta3-adrenergic receptor gene in Japanese subjects.Semantic proximity Read ↗

[Investigation and comparison of the beta3-adrenergic receptor gene Trp64Arg mutation in the Chinese and Japanese].Semantic proximity Read ↗

Beta3-adrenergic receptor gene polymorphism is not associated with hypertension in NIDDM patients without nephropathy.Semantic proximity Read ↗

[Polymorphisms of Arg389Gly of β1-adrenergic receptor gene and essential hypertension risk: a meta analysis].Semantic proximity Read ↗

Association of beta3-adrenergic receptor gene polymorphism with insulin resistance in Japanese-American men.Semantic proximity Read ↗

Clinical features associated with the homozygous Trp64Arg mutation of the beta3-adrenergic receptor: no evidence for its association with obesity in Japanese.Semantic proximity Read ↗

The significance of the Trp 64 Arg mutation of the beta3-adrenergic receptor gene in impaired glucose tolerance, non-insulin-dependent diabetes mellitus, and insulin resistance in Japanese subjects.Semantic proximity Read ↗

Human beta2-adrenergic receptor polymorphisms: no association with essential hypertension in black or white Americans.Semantic proximity Read ↗

The mutation of Trp64Arg in β3-adrenoreceptor-encoding gene is significantly associated with increased hypertension risk and elevated blood pressure: a meta-analysis.Semantic proximity Read ↗

Genotype Arg/Arg, but not Trp/Arg, of the Trp64Arg polymorphism of the beta(3)-adrenergic receptor is associated with type 2 diabetes and obesity in a large Japanese sample.Semantic proximity Read ↗

Trp64Arg mutation in beta 3-adrenoceptor gene of doubtful significance for obesity and insulin resistance.Semantic proximity Read ↗

Association of Trp64Arg beta 3-adrenergic-receptor gene polymorphism with essential hypertension in the Sardinian population.Semantic proximity Read ↗

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