Article
Trp64Arg mutation of beta3-adrenergic receptor in essential hypertension: insulin resistance and the adrenergic system.
American journal of hypertension - 1 Jan 1997
Fujisawa T, Ikegami H, Yamato E, Hamada Y, Kamide K, Rakugi H, Higaki J, Murakami H, Shimamoto K, Ogihara T
Abstract excerpt
A putative pathogenic mutation in the beta3-adrenergic receptor gene (Trp64Arg) has been reported to be associated with higher diastolic blood pressure as well as clinical features of the insulin resistance syndrome and an earlier onset of non-insulin-dependent diabetes mellitus (NIDDM) in Pima I...
Topics
- Adult
- Aged
- Arginine
- Disease Susceptibility
- Female
- Humans
- Hypertension
- Insulin Resistance
- Male
- Middle Aged
- Mutation
- Receptors, Adrenergic, beta
- Tryptophan