Article
The radioprotector WR-2721 reduces neutron-induced mutations at the hypoxanthine-guanine phosphoribosyl transferase locus in mouse splenocytes when administered prior to or following irradiation.
Carcinogenesis - 1 May 1992
Grdina D J, Kataoka Y, Basic I, Perrin J
Abstract excerpt
An in vitro T-lymphocyte cloning technique has been applied to study the effects of JANUS fission-spectrum neutron irradiation and the radioprotector S-2-(3-aminopropylamino) ethylphosphorothioic acid (WR-2721) on the subsequent development of somatic mutations at the hypoxanthine-guanine phosphoribosyl transferase (hprt) locus in hybrid B6CF1 male mice. In control studies performed to establish an in vitro...
Topics
- Amifostine
- Animals
- Drug Administration Schedule
- Hypoxanthine Phosphoribosyltransferase
- Male
- Mice
- Mutation
- Neutrons
- Radiation Dosage
- Spleen
- T-Lymphocytes