Article
Importance of structural differences between complementary RNA molecules to control of replication of an IncB plasmid.
Journal of bacteriology - 1 Feb 1997
Wilson I W, Siemering K R, Praszkier J, Pittard A J
Abstract excerpt
Replication of the IncB miniplasmid pMU720 is dependent on the expression of repA, the gene encoding replication initiator protein RepA. Binding of a small antisense RNA (RNAI) to its complementary target (stem-loop I [SLI]) in the RepA mRNA prevents the participation of SLI in the formation of a pseudoknot that is an enhancer of translation of this mRNA. Thus, RNAI regulates the frequency of replication of...
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