Article
Mutational analysis of VAMP domains implicated in Ca2+-induced insulin exocytosis.
The EMBO journal - 16 Dec 1996
Regazzi R, Sadoul K, Meda P, Kelly R B, Halban P A, Wollheim C B
Abstract excerpt
Vesicle-associated membrane protein-2 (VAMP-2) and cellubrevin are associated with the membrane of insulin-containing secretory granules and of gamma-aminobutyric acid (GABA)-containing synaptic-like vesicles of pancreatic beta-cells. We found that a point mutation in VAMP-2 preventing targeting to synaptic vesicles also impairs the localization on insulin-containing secretory granules, suggesting a similar...
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