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Article

A Central Small Amino Acid in the VAMP2 Transmembrane Domain Regulates the Fusion Pore in Exocytosis.

Scientific reports - 6 Jun 2017

Hastoy Benoît, Scotti Pier A, Milochau Alexandra, Fezoua-Boubegtiten Zahia, Rodas Jorge, Megret Rémi, Desbat Bernard, Laguerre Michel, Castano Sabine, Perrais David, Rorsman Patrik, Oda Reiko, Lang Jochen

Abstract excerpt

Exocytosis depends on cytosolic domains of SNARE proteins but the function of the transmembrane domains (TMDs) in membrane fusion remains controversial. The TMD of the SNARE protein synaptobrevin2/VAMP2 contains two highly conserved small amino acids, G100 and C103, in its central portion. Substituting G100 and/or C103 with the β-branched amino acid valine impairs the structural flexibility of the TMD in terms of...

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Identifiers

PMID: 28588281
DOI: 10.1038/s41598-017-03013-3
PMCID: PMC5460238

Genes

VAMP2

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