Article
A targeting signal in VAMP regulating transport to synaptic vesicles.
Cell - 19 May 1995
Grote E, Hao J C, Bennett M K, Kelly R B
Abstract excerpt
VAMP is a synaptic vesicle membrane protein required for fusion. Synaptic vesicle targeting was measured for mutants of an epitope-tagged form of VAMP in transfected PC12 cells. A signal within a predicted amphipathic alpha helix is essential for targeting to synaptic vesicles. Cellubrevin, a non...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Biological Transport
- Conserved Sequence
- Membrane Proteins
- Molecular Sequence Data
- Mutation
- Nerve Tissue Proteins
- PC12 Cells
- Peptide Mapping
- Qa-SNARE Proteins
- R-SNARE Proteins
- Rats
- Synaptic Vesicles