Rearrangement and reactivation of the myelin basic protein locus in myelin-deficient (mld) mouse brain.

doi:10.1046/j.1471-4159.1997.68020457.x

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Article

Rearrangement and reactivation of the myelin basic protein locus in myelin-deficient (mld) mouse brain.

Journal of neurochemistry - 1 Feb 1997

Sun Y, Xu J, Barbarese E, Carson J H

Abstract excerpt

Myelin-deficient (mld) is a complex mutation affecting the myelin basic protein (MBP) locus of the mouse. It consists of duplication and partial inversion of the MBP gene and results in a dysfunctional MBP locus. The mutant phenotype is reversed, both in vivo and in vitro, in approximately 5% of mld oligodendrocytes. One possible mechanism for the somatic reversion is recombination between homologous sequences of...

Topics

Animals
Brain Chemistry
Cells, Cultured
DNA Nucleotidyltransferases
DNA Primers
DNA, Circular
Female
Gene Expression
Gene Rearrangement
Genetic Variation
Male
Mice
Mice, Mutant Strains
Myelin Basic Protein
Myelin Sheath
Oligodendroglia
Polymerase Chain Reaction
VDJ Recombinases

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PMID: 9003030
DOI: 10.1046/j.1471-4159.1997.68020457.x

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