Article
Molecular genetic analysis of the mldr mouse: a spontaneous revertant at the mld locus containing a recombinant myelin basic protein gene.
Genetics - 1 Feb 1992
Ainger K, Barbarese E, Berman L, Carson J H
Abstract excerpt
The mld mutation is a complex genetic lesion affecting the myelin basic protein (MBP) locus in the mouse. The mutation consists of a variety of DNA rearrangements including: tandem duplication of the MBP structural gene, partial inversion of the 3' end of the upstream gene copy, duplication of a region flanking the rearrangement junction in the upstream copy and insertion between the two gene copies of a segment...
Topics
- Alleles
- Animals
- Base Sequence
- DNA
- DNA Mutational Analysis
- Female
- Male
- Mice
- Mice, Mutant Strains
- Molecular Sequence Data
- Mutation
- Myelin Basic Protein