Article
Linker insertion analysis of the FimH adhesin of type 1 fimbriae in an Escherichia coli fimH-null background.
FEMS microbiology letters - 1 Apr 1996
Schembri M A, Pallesen L, Connell H, Hasty D L, Klemm P
Abstract excerpt
The gene encoding the Escherichia coli FimH adhesin of type 1 fimbriae has been subjected to linker insertion mutagenesis. Amino acid changes were introduced at a number of positions spanning the entire sequence in order to probe the structure-function relationship of the FimH protein. The effect of these mutations on the ability of bacteria to express a D-mannose binding phenotype was assessed in a fimH null...
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