The CD4-independent tropism of human immunodeficiency virus type 2 involves several regions of the envelope protein and correlates with a reduced activation threshold for envelope-mediated fusion.

doi:10.1128/JVI.71.2.1453-1465.1997

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Article

The CD4-independent tropism of human immunodeficiency virus type 2 involves several regions of the envelope protein and correlates with a reduced activation threshold for envelope-mediated fusion.

Journal of virology - 1 Feb 1997

Reeves J D, Schulz T F

Abstract excerpt

Several human immunodeficiency virus type 2 (HIV-2) strains have been shown to infect some CD4-negative cell lines (P. R. Clapham, A. McKnight, and R. A. Weiss, J. Virol. 66:3531-3537, 1992). Using molecular clones of HIV-2 with a CD4-independent tropism, we have identified critical amino acid re...

Topics

CD4 Antigens
CD4-Positive T-Lymphocytes
Gene Expression Regulation, Viral
Genes, Viral
HIV Infections
HIV-2
Humans
Mutation
Viral Envelope Proteins
Virus Replication

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