Article
Decreased plasticity of coreceptor use by CD4-independent SIV Envs that emerge in vivo.
Retrovirology - 12 Nov 2013
Francella Nicholas, Elliott Sarah T C, Yi Yanjie, Gwyn Sarah E, Ortiz Alexandra M, Li Bing, Silvestri Guido, Paiardini Mirko, Derdeyn Cynthia A, Collman Ronald G
Abstract excerpt
BACKGROUND: HIV and SIV generally require CD4 binding prior to coreceptor engagement, but Env can acquire the ability to use CCR5 independently of CD4 under various circumstances. The ability to use CCR5 coupled with low-to-absent CD4 levels is associated with enhanced macrophage infection and increased neutralization sensitivity, but the additional features of these Envs that may affect cell targeting is not...
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