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Article

Infectious properties of human immunodeficiency virus type 1 mutants with distinct affinities for the CD4 receptor.

Journal of virology - 1 Feb 1997

Platt E J, Madani N, Kozak S L, Kabat D

Abstract excerpt

Recent evidence suggests that primary patient isolates of T-cell-tropic human immunodeficiency virus type 1 (HIV-1 ) have lower affinities for CD4 than their laboratory-adapted derivatives, that this may partly result from tighter gp120-gp41 bonds that constrain the CD4 binding sites of the prima...

Topics

Acquired Immunodeficiency Syndrome
Binding Sites
CD4 Antigens
HIV Envelope Protein gp120
HIV-1
HeLa Cells
Humans
Mutation
Virulence

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 8995604
DOI: 10.1128/JVI.71.2.883-890.1997
PMCID: PMC191135

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8995604-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Infectious properties of human immunodeficiency virus type 1 mutants with distinct affinities for the CD4 receptor.PMID 8995604Read ↗

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