Article
Determinants of CD4 independence for a human immunodeficiency virus type 1 variant map outside regions required for coreceptor specificity.
Journal of virology - 1 Dec 1999
LaBranche C C, Hoffman T L, Romano J, Haggarty B S, Edwards T G, Matthews T J, Doms R W, Hoxie J A
Abstract excerpt
Although infection by human immunodeficiency virus (HIV) typically requires an interaction between the viral envelope glycoprotein (Env), CD4, and a chemokine receptor, CD4-independent isolates of HIV and simian immunodeficiency virus have been described. The structural basis and underlying mechanisms for this phenotype are unknown. We have derived a variant of HIV-1/IIIB, termed IIIBx, that acquired the ability...
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