Article
Differential regulation of cellular tropism and sensitivity to soluble CD4 neutralization by the envelope gp120 of human immunodeficiency virus type 1.
Journal of virology - 1 Aug 1994
Stamatatos L, Werner A, Cheng-Mayer C
Abstract excerpt
Using recombinant and mutant viruses generated between two human immunodeficiency virus type 1 isolates that display differences in cell tropism and sensitivity to soluble CD4 neutralization, we show that these two properties of the virus are regulated by different mechanisms. Whereas there is an...
Topics
- Amino Acid Sequence
- Animals
- Antibodies, Monoclonal
- CD4 Antigens
- Cell Line
- HIV Envelope Protein gp120
- HIV Envelope Protein gp41
- HIV-1
- Humans
- Molecular Sequence Data
- Neutralization Tests
- Peptide Fragments
- Phenotype
- Protein Conformation
- Solubility
- Transfection