Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CD4, CXCR-4, and CCR-5 dependencies for infections by primary patient and laboratory-adapted isolates of human immunodeficiency virus type 1.

Journal of virology - 1 Feb 1997

Kozak S L, Platt E J, Madani N, Ferro F E, Peden K, Kabat D

Abstract excerpt

We have used a focal infectivity method to quantitatively analyze the CD4, CXCR-4, and CCR-5 dependencies for infections by diverse primary patient (PR) and laboratory-adapted (LA) isolates of human immunodeficiency virus type 1 (HIV-1). Infectivities of T-cell-tropic viruses were analyzed in a panel of HeLa-CD4 cell clones that have distinct quantities of CD4 and in human astroglioma U87MG-CD4 cells that express...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acquired Immunodeficiency Syndrome
Share to CD4 Antigens

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to HeLa Cells

Share to HIV Envelope Protein gp120

Share to Membrane Proteins

Share to Mutation

Share to T-Lymphocyte Subsets

Source

Open in PubMed Open full text

Identifiers

PMID: 8995603
DOI: 10.1128/JVI.71.2.873-882.1997
PMCID: PMC191134

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CD4, CXCR-4, and CCR-5 dependencies for infections by primary patient and laboratory-adapted isolates of human immunodeficiency virus type 1.PMID 8995603Read ↗

Differences in CD4 dependence for infectivity of laboratory-adapted and primary patient isolates of human immunodeficiency virus type 1Semantic proximity Read ↗

Infectious properties of human immunodeficiency virus type 1 mutants with distinct affinities for the CD4 receptor.Semantic proximity Read ↗

Effects of CCR5 and CD4 Cell Surface Concentrations on Infections by Macrophagetropic Isolates of Human Immunodeficiency Virus Type 1Semantic proximity Read ↗

Coreceptor usage of primary human immunodeficiency virus type 1 isolates varies according to biological phenotype.Semantic proximity Read ↗

Critical role of enhanced CD4 affinity in laboratory adaptation of human immunodeficiency virus type 1.Semantic proximity Read ↗

Preferential use of CXCR4 by R5X4 human immunodeficiency virus type 1 isolates for infection of primary lymphocytes.Semantic proximity Read ↗

Primary, syncytium-inducing human immunodeficiency virus type 1 isolates are dual-tropic and most can use either Lestr or CCR5 as coreceptors for virus entrySemantic proximity Read ↗

Neutralization Sensitivity of Human Immunodeficiency Virus Type 1 Primary Isolates to Antibodies and CD4-Based Reagents Is Independent of Coreceptor UsageSemantic proximity Read ↗

Determination of coreceptor usage of human immunodeficiency virus type 1 from patient plasma samples by using a recombinant phenotypic assay.Semantic proximity Read ↗

Primary Human Immunodeficiency Virus Type 2 (HIV-2) Isolates, Like HIV-1 Isolates, Frequently Use CCR5 but Show Promiscuity in Coreceptor UsageSemantic proximity Read ↗

A broad range of chemokine receptors are used by primary isolates of human immunodeficiency virus type 2 as coreceptors with CD4.Semantic proximity Read ↗

Differences in chemokine coreceptor usage between genetic subtypes of HIV-1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.