Article
Differences in chemokine coreceptor usage between genetic subtypes of HIV-1.
Virology - 15 Feb 1998
Tscherning C, Alaeus A, Fredriksson R, Björndal A, Deng H, Littman D R, Fenyö E M, Albert J
Abstract excerpt
HIV-1 uses chemokine coreceptors for cell entry. CXCR4 is the major coreceptor for T-cell-line-adapted isolates and CCR5 for non-T-cell-line-adapted isolates. This study investigated if coreceptor usage differs between genetic subtypes of HIV-1. Eighty-one primary isolates representing nine diffe...
Topics
- Genotype
- HIV Envelope Protein gp120
- HIV-1
- Humans
- Peptide Fragments
- Phenotype
- Receptors, CCR5
- Receptors, CXCR4
- Tumor Cells, Cultured