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Article

A Mouse Model with Features of Familial Combined Hyperlipidemia

17 Jan 1997

Abstract excerpt

Familial combined hyperlipidemia (FCHL) is a common inherited lipid disorder, affecting 1 to 2 percent of the population in Westernized societies. Individuals with FCHL have large quantities of very low density lipoprotein (VLDL) and low density lipoprotein (LDL) and develop premature coronary heart disease. A mouse model displaying some of the features of FCHL was created by crossing mice carrying the human...

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PMID: 8994037
DOI: 10.1126/science.275.5298.391

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