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Article

Arginine mutation alters binding of a human monoclonal antibody to antigens linked to systemic lupus erythematosus and the antiphospholipid syndrome.

Arthritis and rheumatism - 1 Jul 2007

Lambrianides Anastasia, Giles Ian, Ioannou Yiannis, Mason Lesley, Latchman David S, Manson Jessica J, Isenberg David A, Rahman Anisur

Abstract excerpt

OBJECTIVE: Previous studies have shown the importance of somatic mutations and arginine residues in the complementarity-determining regions (CDRs) of pathogenic anti-double-stranded DNA (anti-dsDNA) antibodies in human and murine lupus, and in studies of murine antibodies, a role of mutations at position 53 in V(H) CDR2 has been demonstrated. We previously demonstrated in vitro expression and mutagenesis of the...

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Source

Identifiers

PMID: 17599767
DOI: 10.1002/art.22743

Genes

GPI
CDR2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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