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Article

Epidermal morphogenesis and keratin expression in c-Ha-ras-transfected tumorigenic clones of the human HaCaT cell line.

Cancer research - 15 Aug 1991

Breitkreutz D, Boukamp P, Ryle C M, Stark H J, Roop D R, Fusenig N E

Abstract excerpt

Several tumorigenic (benign and malignant) clones have been raised from the human epidermal cell line HaCaT after transfection with the c-Ha-ras oncogene (val 12) (P. Boukamp et al., Cancer Res., 50: 2840-2847, 1990). In culture, these HaCaT-ras clones expressed epidermal differentiation markers, such as keratins K1 and 10, at high density or upon depletion of retinoic acid. Accordingly, as HaCaT cells, the...

Topics

Cell Line
Cell Transformation, Neoplastic
Clone Cells
Cytoskeletal Proteins
Epidermal Cells
Fluorescent Antibody Technique
Genes, ras
Humans
Keratins
Morphogenesis
Phenotype

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Transfection

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Identifiers

PMID: 1714343

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1714343-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Epidermal morphogenesis and keratin expression in c-Ha-ras-transfected tumorigenic clones of the human HaCaT cell line.PMID 1714343Read ↗

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