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Article

Activation of human plasminogen by staphylokinase. Direct evidence that preformed plasmin is necessary for activation to occur.

Blood - 1 Mar 1997

Grella D K, Castellino F J

Abstract excerpt

To directly determine whether the mechanism of activation of human plasminogen (HPg) by staphylokinase (Sak) required formation of an active complex of Sak and HPg, recombinant (r) variants of HPg were examined that allowed dissection of the steps involved in this activation. The rate of activation of wild-type (wt) r-HPg by equimolar levels of Sak was enhanced when small amounts of human plasmin (HPm) were...

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Source

Identifiers

PMID: 9057640

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Activation of human plasminogen by staphylokinase. Direct evidence that preformed plasmin is necessary for activation to occur.PMID 9057640Read ↗

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Role of Staphylokinase in the Acquisition of Plasmin(ogen)-Dependent Enzymatic Activity by StaphylococciSemantic proximity Read ↗

Structural and functional basis of plasminogen activation by staphylokinase.Semantic proximity Read ↗

Plasminogen substrate recognition by the streptokinase-plasminogen catalytic complex is facilitated by Arg253, Lys256, and Lys257 in the streptokinase beta-domain and kringle 5 of the substrate.Semantic proximity Read ↗

Plasminogen activator activities of equimolar complexes of streptokinase with variant recombinant plasminogens.Semantic proximity Read ↗

Role of the N-terminal region of staphylokinase (SAK): evidence for the participation of the N-terminal region of SAK in the enzyme-substrate complex formation.Semantic proximity Read ↗

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Rapid-reaction kinetic characterization of the pathway of streptokinase-plasmin catalytic complex formation.Semantic proximity Read ↗

Staphylokinase as a Plasminogen Activator Component in Recombinant Fusion ProteinsSemantic proximity Read ↗

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